Dopamine D2 receptor binding is reduced in Wilson's disease: Correlation of neurological deficits with striatal123I-Iodobenzamide binding
Identifieur interne : 002189 ( Main/Exploration ); précédent : 002188; suivant : 002190Dopamine D2 receptor binding is reduced in Wilson's disease: Correlation of neurological deficits with striatal123I-Iodobenzamide binding
Auteurs : W. Oder [Autriche] ; T. Brücke [Autriche] ; H. Kollegger [Autriche] ; J. Spatt [Autriche] ; S. Asenbaum [Autriche] ; L. Deecke [Autriche]Source :
- Journal of Neural Transmission [ 0300-9564 ] ; 1996-08-01.
Abstract
Summary: To visualise and quantify dopamine D2 receptor binding in the corpus striatum of patients with neurological Wilson's disease (WD) 123I-Iodobenzamide (IBZM) binding was measured using single photon emission computer tomography (SPECT). Ratios of striatal to frontal countrates were calculated in 8 patients and in 21 healthy control subjects. We found reduced IBZM binding ratios in all patients with WD in comparison to those in controls (1.48 +- 0.13 vs. 1.73 +- 0.09). The reduction in IBZM binding was correlated with the overall severity of neurological deficits and the severity of dysarthria (correlation coefficients −0.86 [p < 0.01] and −0.79 [p s< 0.01], respectively). When patients of three different subgroups of neurological WD were compared no differences in IBZM binding were found. We conclude that assessing basal ganglia function in vivo using IBZM-SPECT is a valuable diagnostic tool in WD.
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DOI: 10.1007/BF01291794
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Neural Transmission</title><idno type="ISSN">0300-9564</idno><idno type="eISSN">1435-1463</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><date type="published" when="1996-08-01">1996-08-01</date><biblScope unit="volume">103</biblScope><biblScope unit="issue">8-9</biblScope><biblScope unit="page" from="1093">1093</biblScope><biblScope unit="page" to="1103">1103</biblScope></imprint><idno type="ISSN">0300-9564</idno></series><idno type="istex">42D97EF787C9E5EA9014A21E1E08D542EFC40EB7</idno><idno type="DOI">10.1007/BF01291794</idno><idno type="ArticleID">Art15</idno><idno type="ArticleID">BF01291794</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0300-9564</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: To visualise and quantify dopamine D2 receptor binding in the corpus striatum of patients with neurological Wilson's disease (WD) 123I-Iodobenzamide (IBZM) binding was measured using single photon emission computer tomography (SPECT). Ratios of striatal to frontal countrates were calculated in 8 patients and in 21 healthy control subjects. We found reduced IBZM binding ratios in all patients with WD in comparison to those in controls (1.48 +- 0.13 vs. 1.73 +- 0.09). The reduction in IBZM binding was correlated with the overall severity of neurological deficits and the severity of dysarthria (correlation coefficients −0.86 [p < 0.01] and −0.79 [p s< 0.01], respectively). When patients of three different subgroups of neurological WD were compared no differences in IBZM binding were found. We conclude that assessing basal ganglia function in vivo using IBZM-SPECT is a valuable diagnostic tool in WD.</div></front></TEI><affiliations><list><country><li>Autriche</li></country><region><li>Vienne (Autriche)</li></region><settlement><li>Vienne (Autriche)</li></settlement></list><tree><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Oder, W" sort="Oder, W" uniqKey="Oder W" first="W." last="Oder">W. Oder</name></region><name sortKey="Asenbaum, S" sort="Asenbaum, S" uniqKey="Asenbaum S" first="S." last="Asenbaum">S. Asenbaum</name><name sortKey="Brucke, T" sort="Brucke, T" uniqKey="Brucke T" first="T." last="Brücke">T. Brücke</name><name sortKey="Deecke, L" sort="Deecke, L" uniqKey="Deecke L" first="L." last="Deecke">L. Deecke</name><name sortKey="Kollegger, H" sort="Kollegger, H" uniqKey="Kollegger H" first="H." last="Kollegger">H. Kollegger</name><name sortKey="Spatt, J" sort="Spatt, J" uniqKey="Spatt J" first="J." last="Spatt">J. Spatt</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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